Calcium antagonism without negative inotropy?
نویسندگان
چکیده
منابع مشابه
Increased calcium loading and inotropy without greater cell death in hypoxic rat cardiomyocytes.
To test whether contractile function in "hypoxic" myocytes treated with high glucose (19.5 mM) can be improved by increasing intracellular Ca2+ without accelerating cell contracture or death, we challenged metabolically inhibited, paced myocytes with high extracellular Ca2+ concentration ([Ca2+]o) and measured simultaneously cell shortening and intracellular Ca2+ concentration ([Ca2+]i). NaCN e...
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Dear Sir: The purpose of the study and the interpretation of the data by Fuchs et al. (1968) was based on the generally held assumption that quinidine has only opposite contractile effects on skeletal muscle and cardiac muscle. As the authors indicated, quinidine potentiates twitch tension in skeletal muscle, and at high concentrations causes contracture (Isaacson and Sandow, 1967), whereas in ...
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ژورنال
عنوان ژورنال: Journal of the American College of Cardiology
سال: 1990
ISSN: 0735-1097
DOI: 10.1016/0735-1097(90)92063-8